Depending on your equipment, you can kill bosses with 2-3(1 if you have good stuff) tetra punch without using Debuffs. My bunny for example kills count with 1-2 tetras, thus casting debuff isnt necessary. Same with Odinea. I can kill odinea with 2 tetra's whether or not i use debuff. What i noticed is that guard break + faint and luck breaker doesn't help much since even with guard break your melee attacks can still miss and even with luck breaker her AR still hits(i have 180+LK + mastered Luck breaker). Just back yourself up with good HP. my char has only 22k and does die from her AR. So Basically for me its just, Tetra, Run(then heal if she ARed me), Tetra.
p.s. hahaha i didnt know its an old thread. funny i know LOL