Alice is captured by Umbrella and awakens in the heart of their operation facility; as she moves further in the complex more of her past is unveiled and continues to hunt for those responsible for the outbreak. Her quest takes her and her newfound allies from Tokyo to New York, Washington, D.C. and Moscow. After a "mind-blowing" revelation, she is forced to rethink everything she once thought to be true.
The film has many returning actors and characters, along with new characters from the video game not featured in the films. Filming took place from October to December 2011 for a scheduled release date of September 14, 2012.