ArPen Marks and Quints
Flat Armour/Dodge Yellows
Flat Magic Res Blues
Scaling defence will result in you dying a lot early game
Start with Dorans Shield. Gives you about 50 of both resists and 600 HP. You sacrifice points in offense for an easier laning phase which leads to a stronger late-game. The 21 points are made up easily late-game due to Twitch's superior damage.
I haven't lost a game with twitch like this <3 Works great in solo queue.