I... have to agree a bit. I had much less lag on the over crowded THQ server with one channel.
The monsters movements are laggy, my attack damage registering is slower, and my 'dodges' work a lot less due to the game not registering them as quickly.
I an run and shoot quickly, but having things register as actions is a lot slower. Even looting. (I will never get boss loot again, seriously. ^^;; It's long gone by the time I see where it fell. )