wouldn't hurt I suppose.
My speedloader is only at level 7 or so right now, I don't see too much of a difference between having the buff on or not, takes off about one loading message if I spam click on something after a regular shot on another monster. Using an alt maiden queen gun, so results may vary.
gun overdrive can be handy with high gun ap as well since it can enable normal shots to ohko at times they wouldn't otherwise, I tend to just go with skills most of the time, but it's something to keep in mind.
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